Anti-Aging Center

Vitamin D is very important vitamin and has many therapeutic benefits:

1. Helps for musculoskeletal pain
2. Also has neurotransmitter and neurologic function
3. It also affects the immune system by having anti-inflammatory affects

Vitamin D has therapeutic benefit in

• Cardiovascular disease
•  Hypertension
• Diabetes
• Osteoarthritis
• MS
• Depression
• Epilepsy
• Migraine headaches
• Polycystic ovaries
• Autoimmune Inflammatory conditions
• Musculoskeletal pain
• Cancer prevention and treatment
• Fibromyalgia

Dose of Vitamin D

• Doses of vitamin D should be in the range of 3,000-10,000 IU
• Recommend 4,000 IU per day for adults
• Full body exposure to UV light can produce 10,000-25,000 IU of vitamin D3 per day
• Supplementation should be with D3 not D2

  Vitamin D absorption is decreased by

• Sunscreen-topical sunscreen block vitamin D production by 97-100%
•  Skin pigmentation
•  Body fat
• Age: 70 y/o produces 4x less than 20y/o
• Drugs
• Clothing
• Latitude > 37 in winter, Early and late hours
• Anticonvulsants, corticosteroids, rifampin

   Foods Contain Vitamin D

•  One whole egg, 20 IU
•  Fortified Milk 1 cup 100 IU
• Cod liver oil, 1 Tbs (15 mL) 1,360 IU
• Fatty fish species,:

– Herring 85g (3 oz) 1383 units

– Cat fish, 85g (3 oz) 425 IU

– Salmon, cooked, 3.5 oz 360 IU

Vitamin D deficiency can cause

• Increased bone loss
• Osteoporosis & Decreased BMD
• Increased fragility and fracture risk
• Muscle weakness  & Childhood bone health
• Secondary hyperparathyroidism
• Periodontal disease
• Infectious disease and more

Cardiovascular Disease:  Deaths from heart disease are more common in the winter months and the risk of MI is twice as high if 25(O)D are low

Diabetes: Low vitamin D is associated with IR and beta-cell dysfunction. Metformin improves insulin sensitivity by 13%, higher vitamin D correlates with a 60% improvement in insulin sensitivity

Osteoarthritis: The progression of osteoarthritis is lessened by adequate vitamin D.

Multiple Sclerosis: The progression of osteoarthritis is lessened by adequate vitamin D.

Depression: Patient who supplemented with 400 or 800 IU of vitamin D qd had significant improvement of mood.

Migraine headache: Study showed a reduction in frequency,   duration, and severity of menstrual migraines, in women with vitamin D deficiency, with daily supplementation with 1,200 mg of calcium and 1,200-1,600 IU of vitamin D

Musculoskeletal pain: Many patients with non-traumatic, chronic, musculoskeletal pain have a high frequency of vitamin D deficiency.

Study found vitamin D deficiency in 83% of 299 patients with low back pain. Supplementation with 5,000-10,000 IU of vitamin D per day decreased pain in almost 100% of these patients in 3 months

• Autoimmune conditions: Besides MS, the following diseases are also associated with vitamin D deficiency like  Grave’s disease, Ankylosing spondylitis, SLE,RA

Anti-inflammatory conditions: Study of vitamin D supplementation showed the anti-inflammatory effect of  vitamin D evidenced by reduction in IL-6  and CRP

Cancer Prevention and Treatment

Inadequate exposure to sunlight is associated with the following cancers:- Breast, Lung, Pancreas, Esophagus, Stomach,  Colon, Rectum, Uterus, Ovary, Bladder, Kidney,  Prostate, Non-Hodgkin Lymphoma,

Fibromyalgia:50% of patients with fibromyalgia are vitamin D deficient.

Vitamin D deficiency is common in women with PCOS.